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Data Mining in Networks of Differentially Expressed Genes during Sow Pregnancy
2015-09-06 08:45     (点击次数:)

Wang L, Zhang L, Li Y, Li W, Luo W, Cheng D, Yan H, Ma X, Liu X, Song X, Liang J, Zhao K.

International Journal of Biological Sciences.2012,8(4):548-560.

Abstract:Small to moderate gains in Pig fertility can mean large returns in overall efficiency, and developing methods to improve it is highly desirable. High fertility rates depend on completion of successful pregnancies. To understand the molecular signals associated with pregnancy insows, expression profiling experiments were conducted to identify differentially expressed genes in ovary and myometrium at different pregnancy periods using the Affymetrix Porcine GeneChipTM. A total of 974, 1800, 335 and 710 differentially expressed transcripts were identified in the myometrium during early pregnancy (EP) and late pregnancy (LP), and in the ovary during EPand LP, respectively. Self-Organizing Map (SOM) clusters indicated the differentially expressed genes belonged to 7 different functional groups. Based on BLASTX searches and Gene On tology (GO) classifications, 129 unique genes closely related to pregnancy showed differential expression patterns. GO analysis also indicated that there were 21 different molecular function categories, 20 different biological process categories, and 8 different cellular component categories of genes differentially expressed during sow pregnancy. Gene regulatory network reconstruction provided us with aninter action model of known genes such as insulin-like growth factor 2 (IGF2)gene, estrogen receptor (ESR) gene, retinol-binding protein-4 (RBP4) gene, and several unknown candidate genes related to reproduction. Several pitch point genes were selected for association study with reproduction traits. Forinstance, DPPA5 g.363 T>C was found to associate with litter born weight at later parities in Beijing Black pigs significantly (p < 0.05). Over all, this study contributes to elucidating the mechanism underlying pregnancy processes,which maybe provide valuable information for pig reproduction improvement.

Keywords:genenet work;microarray; myometrium; ovary;sow pregnancy

原文链接:http://www.ijbs.com/v08p0548.htm

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